Trends in Psychiatry and Psychotherapy
https://trends.org.br/article/doi/10.1590/2237-6089-2018-0057
Trends in Psychiatry and Psychotherapy
Original Article

Relationship between sexual hormones, quality of life and postmenopausal sexual function

Relação entre hormônios sexuais, qualidade de vida e função sexual na pós-menopausa

Clayton Peixoto; Carolina Gomes Carrilho; Tatiana Teixeira de Siqueira Bilemjian Ribeiro; Lucy Maria da Silva; Emerson Andrade Gonçalves; Luísa Fernandes; Antonio Egidio Nardi; Adriana Cardoso; André Barciela Veras

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Abstract

Abstract Objective To assess the relationship between sexual hormones, sexual function and quality of life in postmenopausal women. Method A cross-sectional study was conducted with a convenience sample of 36 postmenopausal women between the ages of 45 and 65 in follow-up at a climacteric outpatient clinic. Mood, quality of life, sexual function and hormonal profile were assessed. Results With regard to sexual hormones and sexual function, a relationship was found between orgasm and luteinizing hormone (r=0.37), orgasm and sex hormone-binding globulin (SHBG) (r=0.39), SHBG and less pain (r=0.44), dehydroepiandrosterone (DHEA) and desire (r=-0.45), as well as between prolactin and lubrication (r=0.33). Sexual hormones and quality of life were related as follows: progesterone and limitations due to physical aspects (r=0.35), SHBG and social aspects (r=0.35), cortisol and pain (r=0.46), DHEA and social aspects (r=-0.40). Finally, the following relationships were found between sexual function and quality of life: sexual desire and vitality, social aspects, state of general health and mental health (r=0.46, r=0.51, r=0.35, and r=0.38, respectively). Arousal, orgasm and satisfaction with sexual life showed a relationship with less physical pain (r=0.40, r=0.42, and r=0.43, respectively). Satisfaction with sexual life was correlated with vitality (r=0.33). Conclusion Different correlations than expected were found in this study regarding the effect of some hormones on sexual function and some aspects of the quality of life of postmenopausal women.

Keywords

Sexual hormones, sexual dysfunction, well-being, quality of life, women, postmenopausal

Resumo

Resumo Objetivo Avaliar a relação entre hormônios sexuais, função sexual e qualidade de vida em mulheres na pós-menopausa. Métodos Estudo transversal com amostra de conveniência de 36 mulheres na pós-menopausa, com idades entre 45 e 65 anos, em seguimento ambulatorial de climatério. Humor, qualidade de vida, função sexual e perfil hormonal foram avaliados. Resultados Entre hormônios sexuais e função sexual, foi encontrada relação entre orgasmo e hormônio luteinizante (r=0,37), orgasmo e globulina ligadora de hormônios sexuais (SHBG) (r=0,39), SHBG e menos dor (r=0,44), desidroepiandrosterona (DHEA) e desejo (r=-0,45), bem como entre prolactina e lubrificação (r=0,33). Entre hormônios sexuais e qualidade de vida: progesterona e limitações por aspectos físicos (r=0,35), SHBG e aspectos sociais (r=0,35), cortisol e dor (r=0,46), DHEA e aspectos sociais (r=-0,40). Por fim, entre função sexual e qualidade de vida: desejo sexual e vitalidade, aspectos sociais, estado geral de saúde e saúde mental (r=0,46, r=0,51, r=0,35 e r=0,38, respectivamente). Excitação, orgasmo e satisfação com a vida sexual mostraram uma relação com menos dor física (r=0,40, r=0,42 e r=0,43, respectivamente). A satisfação com a vida sexual foi correlacionada com a vitalidade (r=0,33). Conclusão Correlações diferentes das esperadas foram encontradas neste estudo em relação ao efeito de alguns hormônios sobre a função sexual e alguns aspectos da qualidade de vida de mulheres na pós-menopausa.

Palavras-chave

Hormônios sexuais, disfunção sexual, bem-estar, qualidade de vida, mulheres, pós-menopausa

References

Pedro AO, Pinto Neto AM, Costa-Paiva LHS, Osis MJD, Hardy EE. Síndrome do climatério: inquérito populacional domiciliar em Campinas, SP. Rev Saude Publica. 2003;37:735-42.

Lui Filho JF, Baccaro LFC, Fernandes T, Conde DM, Costa-Paiva L, Pinto NAM. Factors associated with menopausal symptoms in women from a metropolitan region in southeastern Brazil: a population-based household survey. Rev Bras Ginecol Obstet. 2015;37:152-8.

Labrie F, Archer D, Bouchard C, Fortier M, Cusan L, Gomez JL. Lack of influence of iyspareunia on the beneficial effect of intravaginal prasterone (dehydroepiandrosterone, DHEA) on sexual dysfunction in postmenopausal women. J Sex Med. 2014;11:1766-85.

Meyer P. Testosterone therapy in female hypoactive sexual desire disorder. Rev Med Suisse. 2016;12:540-3.

De Lorenzi DRS, Saciloto B. Factors related to frequency of sexual activity of postmenopausal women. Rev Assoc Med Bras. 2006;52:256-60.

Santos MDS, Sala MG. Climaterio y menopausia. Parte II. La Sexualidad en el climaterio. Sexol Soc. 1999;5:17-9.

De Paula FJF, Baracat EC, Haidar MA, Lima JGR, Zanetti A, Simões RD. Disfunção sexual no climatério. Femina. 2002;30:373-6.

Tairova OS, De Lorenzi DRS. Influence of exercise in the quality of life of postmenopausal women: a case-control study. Rev Bras Geriatr Gerontol. 2011;14:135-45.

Zahar SEV, Aldrighi JM, Pinto NAM, Conde DM, Zahar LO, Russomano F. Quality of life in users and non-users of hormone replacement therapy. Rev Assoc Med Bras. 2005;51:133-8.

Dallanezi G, Nahas EAP, Freire BF, Nahas-Neto J, Corrente JE, Mazeto GMFS. Quality of life of women with low bone mass in postmenopause. Rev Bras Ginecol Obstet. 2011;33:133-8.

Penteado SRL, Fonseca AM, Bagnoli VR, Assis JS, Pinotti JA. Assessment of orgasmic capacity of postmenopausal women. Rev Assoc Med Bras. 2004;50:444-50.

Kulak JJ, Urbanetz AA, Kulak CAM, Borba VZC, Boguszewski CL. Serum androgen concentrations and bone mineral density in postmenopausal ovariectomized and non-ovariectomized women. Arq Bras Endocrinol Metab. 2009;53:1033-9.

Pimenta FAP, Simil FF, Tôrres HOG, Amaral CFS, Rezende CFC, Coelho TOR. Retiree quality of life assessment with SF-36 Questionnaire. Rev Assoc Med Bras. 2008;54:55-60.

Safarinejad MR. Female sexual dysfunction in a population-based study in Iran: prevalence and associated risk factors. Int J Imp Res. 2006;18:382-95.

Guyton AC, Hall JE. Tratado de fisiologia médica. 2006.

Speroff L, Glass RH, Kase NG. O ovário desde a concepção até a senilidade. Endocrinologia ginecológica clínica e infertilidade. 1995.

Wajchenberg BL. Tratado de endocrinologia clínica. 1992.

Wolkowitz OM, Rothschild AJ. Psychoneuroendocrinology: the scientific basis of clinical practice. 2003.

Genazzani AR, Stomati M, Valentino V, Pluchino N, Pot E, Casarosa E. Effect of 1-year, low-dose DHEA therapy on climacteric symptoms and female sexuality. Climacteric. 2011;14:661-8.

Labrie F, Archer D, Bouchard C, Fortier M, Cusan L, Gomez JL. Lack of influence of dyspareunia on the beneficial effect of intravaginal prasterone (dehydroepiandrosterone, DHEA) on sexual dysfunction in postmenopausal women. J Sex Med. 2014;11:1766-85.

Bloch M, Meiboom H, Zaig I, Schreiber S, Abramov L. The use of dehydroepiandrosterone in the treatment of hypoactive sexual desire disorder: a report of gender differences. Eur Neuropsychopharmacol. 2013;23:910-8.

Anand KJS, Phil D, Hickey PR. Pain and its effects in the human neonate and fetus. N Engl J Med. 1987;317:1321-9.

Leão LMCSM, Duarte MPC, Farias MLF. Insuficiência androgênica na mulher e potenciais riscos da reposição terapêutica. Arq Bras Endocrinol Metab. 2005;49:205-16.

Helena PF, Alessandro S, Tsutomu A, José MA. Deficiência androgênica na mulher. Rev Assoc Med Bras. 2010;56:579-82.

Peixoto C, Cheda JND, Nardi AE, Veras AB, Cardoso A. The effects of dehydroepiandrosterone (DHEA) in the treatment of depression and depressive symptoms in other psychiatric and medical illnesses: a systematic review. Curr Drug Targets. 2014;15:901-14.

Viana ESR, Bruno SS, Sousa MBC. Modulation by progesterone of pain sensitivity to mechanical and ischemic stimuli in young and healthy women. Rev Bras Ginecol Obstet. 2008;30:306-11.

Valença CN, Nascimento FJM, Germano RM. Women in the climacteric: reflections on sexual desire, beauty and femininity. Saude Soc. 2010;19:273-85.

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