Trends in Psychiatry and Psychotherapy
https://trends.org.br/article/doi/10.1590/2237-6089-2019-0008
Trends in Psychiatry and Psychotherapy
Original Article

Quality of life in panic disorder: the influence of clinical features and personality traits

Qualidade de vida no transtorno de pânico: a influência de características clínicas e traços de personalidade

Marcos Fidry; Morena Mourao Zugliani; Clarissa Reis do Valle; Renan Machado Martins; Mariana Costa do Cabo; Antonio Egidio Nardi; Rafael Christophe Freire

Downloads: 0
Views: 299

Abstract

Abstract Objective To identify which clinical features and personality traits are associated with quality of life (QoL) in panic disorder (PD) patients. Methods This was a cross-sectional study with PD patients. The brief version of the World Health Organization Quality of Life Questionnaire (WHOQOL-BREF) and the Big Five Inventory (BFI) were used to assess QoL and personality traits respectively. The strength of correlations was measured with Pearson’s, Spearman’s, and point-biserial correlation coefficients. We also performed multiple linear regressions, considering sociodemographic data and scores from clinical scales as independent variables and QoL scores as dependent variables. Results A total of 98 patients were evaluated. Depressive symptoms had a strong negative correlation with QoL and, to a lesser extent, panic and anxiety symptoms were also negatively correlated with QoL. While consciousness, extraversion, and agreeableness had mild positive correlations with QoL, neuroticism had a strong negative correlation. Conclusion Symptoms of depression, anxiety, and panic seem to have a negative impact on the QoL of PD patients. Personality traits, especially neuroticism, may also influence QoL in these patients.

Keywords

Panic disorder, quality of life, personality inventory, major depressive disorder, neuroticism

Resumo

Resumo Objetivo Identificar quais características clínicas e traços de personalidade são mais associados à qualidade de vida (QdV) em pacientes com transtorno de pânico (TP). Métodos Este foi um estudo transversal, realizado em pacientes com TP. A versão breve do Questionário de Qualidade de Vida da Associação Mundial de Saúde (World Health Organization Quality of Life Questionnaire – WHOQOL-BREF) e o Inventário dos Cinco Grande Fatores (Big Five Inventory – BFI) foram utilizados para avaliar QdV e traços de personalidade, respectivamente. A força de associação foi medida através da correlação de Pearson, de Spearman ou ponto bisserial. Foram também realizadas regressões lineares múltiplas, considerando os dados sociodemográficos e escores obtidos nas escalas clínicas como variáveis independentes, e os escores de QdV como variáveis dependentes. Resultados Um total de 98 pacientes foram avaliados. Sintomas depressivos apresentaram uma forte relação negativa com QdV; em menor intensidade, sintomas de TP e ansiosos também se correlacionaram com QdV. Nos domínios de personalidade, enquanto conscienciosidade, extroversão e amabilidade apresentaram uma leve correlação positiva com QdV, neuroticismo apresentou forte correlação negativa. Conclusão Sintomas depressivos, ansiosos e de TP parecem ter forte impacto negativo na QdV dos pacientes com TP. Traços de personalidade, principalmente neuroticismo, podem influenciar QdV nesses pacientes.

Palavras-chave

Transtorno de pânico, qualidade de vida, inventário de personalidade, transtorno depressivo maior, neuroticismo

References

Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). 2013.

Markowitz JS, Weissman MM, Ouellette R, Lish JD, Klerman GL. Quality of life in panic disorder. Arch Gen Psychiatry. 1989;46:984-92.

Cramer V, Torgersen S, Kringlen E. Quality of life and anxiety disorders: a population study. J Nerv Ment Dis. 2005;193:196-202.

Kessler RC, Stang PE, Wittchen HU, Ustun TB, Roy-Burne PP, Walters EE. Lifetime panic-depression comorbidity in the National Comorbidity Survey. Arch Gen Psychiatry. 1998;55:801-8.

Ay-Woan P, Sarah CP, Lyinn C, Tsyr-Jang C, Ping-Chuan H. Quality of life in depression: predictive models. Qual Life Res. 2006;15:39-48.

IsHak WW, Mirocha J, Christensen S, Wu F, Kwock R, Behjat J. Patient-reported outcomes of quality of life, functioning, and depressive symptom severity in major depressive disorder comorbid with panic disorder before and after SSRI treatment in the star*d trial. Depress Anxiety. 2014;31:707-16.

Wilson IB, Cleary PD. Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. JAMA. 1995;273:59-65.

Yen CF, Kuo CY, Tsai PT, Ko CH, Yen JY, Chen TT. Correlations of quality of life with adverse effects of medication, social support, course of illness, psychopathology, and demographic characteristics in patients with panic disorder. Depress Anxiety. 2007;24:563-70.

Kang EH, Kim B, Choe AY, Lee JY, Choi TK, Lee SH. Panic disorder and health-related quality of life: the predictive roles of anxiety sensitivity and trait anxiety. Psychiatry Res. 2015;225:157-63.

Heldt E, Blaya C, Isolan L, Kipper L, Teruchkin B, Otto MW. Quality of life and treatment outcome in panic disorder: cognitive behavior group therapy effects in patients refractory to medication treatment. Psychother Psychosom. 2006;75:183-6.

de-Melo-Neto VL, King AL, Valença AM, Rocha Freire RC, Nardi AE. Respiratory and non-respiratory panic disorder subtypes: clinical and quality of life comparisons. Rev Port Pneumol. 2009;15:859-74.

Briggs AC, Stretch DD, Brandon S. Subtyping of panic disorder by symptom profile. Br J Psychiatry. 1993;163:201-9.

Zugliani MM, Freire RC, Perna G, Crippa JA, Nardi AE. Laboratory, clinical and therapeutic features of respiratory panic disorder subtype. CNS Neurol Disord - Drug Targets. 2015;14:627-35.

Nardi AE, Nascimento I, Valença AM, Lopes FL, Mezzasalma MA, Zin WA. Respiratory panic disorder subtype: Acute and long-term response to nortriptyline, a noradrenergic tricyclic antidepressant. Psychiatry Res. 2003;120:283-93.

Bienvenu OJ, Stein MB, Samuels JF, Onyike CU, Eaton WW, Nestadt G. Personality disorder traits as predictors of subsequent first-onset panic disorder or agoraphobia. Compr Psychiatry. 2009;50:209-14.

Goldberg LR. An Alternative “Description of Personality”: The Big-Five Factor Structure. J Pers Soc Psychol. 1990;59:1216-29.

Freire RC, Lopes FL, Veras AB, Valença AM, Mezzasalma MA, Nascimento I. Personality traits spectrum in panic disorder and major depression. Braz J Psychiatry. 2007;29:31-4.

Bienvenu OJ, Brown C, Samuels JF, Liang KY, Costa PT, Eaton WW. Normal personality traits and comorbidity among phobic, panic and major depressive disorders. Psychiatry Res. 2001;102:73-85.

Carrera M, Herrán A, Ramírez ML, Ayestarán A, Sierra-Biddle D, Hoyuela F. Personality traits in early phases of panic disorder: implications on the presence of agoraphobia, clinical severity and short-term outcome. Acta Psychiatr Scand. 2006;114:417-25.

Rocha Freire RC, Marco MO, Lopes FL, Veras AB, Caldirola D. The Stability of Personality Traits Despite Naturalistic Treatment for Panic Disorder. Ann Depress Anxiety. 2014;1:1-5.

Zugliani MM, Martin-Santos R, Nardi AE, Freire RC. Personality Traits in Panic Disorder Patients With and Without Comorbidities. J Nerv Ment Dis. 2017;205:855-8.

Gao T, Xiang YT, Zhang H, Zhang Z, Mei S. Neuroticism and quality of life: Multiple mediating effects of smartphone addiction and depression. Psychiatry Res. 2017;258:457-61.

Carrera M, Herrán A, Ayuso-Mateos JL, Sierra-Biddle D, Ramírez ML, Ayestarán A. Quality of life in early phases of panic disorder: Predictive factors. J Affect Disord. 2006;94:127-34.

Hollifield M, Katon W, Skipper B, Chapman T, Ballenger JC, Mannuzza S. Panic disorder and quality of life: Variables predictive of functional impairment. Am J Psychiatry. 1997;154:766-72.

Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988;56:893-7.

Beck AT, Ward CH, Mendelsom M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561-71.

Bandelow B. Panic and agoraphobia scale (PAS). 1999.

Guy W. ECDEU assessment manual for psychopharmacology. 1976.

The WHOQOL Group. Psychol Med. 1998;28:551-8.

Fleck MP, Louzada S, Xavier M, Chachamovich E, Vieira G, Santos L. Aplicação da versão em português do instrumento abreviado de avaliação da qualidade de vida “WHOQOL-bref.”. Rev Saude Publica. 2000;34:178-83.

John OP, Robins RW, Pervin LA. Handbook of personality: theory and research. 2008.

Freire RC, Nascimento I, Valença AM, Lopes FL, Mezzasalma MA, M Neto VL. The panic disorder respiratory ratio: A dimensional approach to the respiratory subtype. Rev Bras Psiquiatr. 2013;35:57-62.

Cruz LN, Polanczyk CA, Camey SA, Hoffmann JF, Fleck MP. Quality of life in Brazil: normative values for the WHOQOL-bref in a southern general population sample. Qual Life Res. 2011;20:1123-9.

Hakulinen C, Elovainio M, Pulkki-Råback L, Virtanen M, Kivimäki M, Jokela M. Personality And Depressive Symptoms: Individual Participant Meta-Analysis of 10 Cohort Studies. Depress Anxiety. 2015;32:461-70.

Lamers F, van Oppen P, Comijs HC, Smit JH, Spinhoven P, van Balkom AJ. Comorbidity patterns of anxiety and depressive disorders in a large cohort study: the Netherlands Study of Depression and Anxiety (NESDA). J Clin Psychiatry. 2011;72:341-8.

Mulder RT. Personality pathology and treatment outcome in major depression: a review. Am J Psychiatry. 2002;159:359-71.

McHugh RK, Smits JA, Otto MW. Empirically supported treatments for panic disorder. Psychiatr Clin North Am. 2009;32:593-610.

Barlow DH, Gorman JM, Shear MK, Woods SW. Cognitive-behavioral therapy, imipramine, or their combination for panic disorder: A randomized controlled trial. JAMA. 2000;283:2529-36.

6165ed73a9539510570903d6 trends Articles
Links & Downloads

Trends Psychiatry Psychother

Share this page
Page Sections