Objective
This systematic review is aimed at describing the relationship between psychological resilience and mood disorders. 

Methods
This is a systematic review and meta-analysis. The following databases were searched: PubMed, PsycINFO, and Embase on November 6, 2020. 

Results
23 articles were included, and the majority of the studies included (95.7%) showed a positive impact of psychological resilience in mood disorders. Our meta-analysis showed that individuals with bipolar disorder presented significantly lower levels of psychological resilience as compared to controls (Standardized Mean Difference (SDM): -0.99 [CI 95%: -1.13 – -0.85], p<0.001). In addition, individuals with depression had significantly lower levels of psychological resilience as compared to controls (SDM: -0.71 [CI 95%: -0.81 – -0.61], p<0.001). 

Conclusion
Our results showed that individuals with mood disorders are less resilient than individuals without mood disorders. Our findings reinforce the importance of investigating interventions that may help to increase psychological resilience considering its positive impact in the context of mood disorders.