Trends in Psychiatry and Psychotherapy
https://trends.org.br/article/doi/10.1590/2237-6089-2016-0043
Trends in Psychiatry and Psychotherapy
Review Article

Assessment of inhibitory control in crack and/or cocaine users: a systematic review

Avaliação do controle inibitório em usuários de cocaína e/ou crack: uma revisão sistemática

Fernanda Rasch Czermainski; Alice Rodrigues Willhelm; Álvaro Zaneti Santos; Mayra Pacheco Pachado; Rosa Maria Martins de Almeida

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Abstract

Abstract Objective Impairments involving inhibitory control have been considered central deficits in drug users, but it appears that dysfunctions may be specific to users’ drug of choice. This article aims to review recent findings on inhibitory control impairment in samples of crack and/or cocaine users. Methods Searches were conducted on the PubMed, PsycINFO, and Web of Knowledge databases in two stages according to eligibility criteria. Initially, databases were searched and the titles and abstracts of results were analyzed and then selected articles were read in full. Inclusion criteria were: empirical articles written in English, Portuguese, or Spanish, published in the last ten years and involving the assessment of inhibitory control in crack and/or cocaine users. Results The database searches returned a total of 3,796 titles, 56 of them were selected initially and then a further 20 were excluded. Thirty-six articles were included in this review. In 90% of the studies reviewed the presence of inhibitory control deficits was reported, verified by impaired cognitive processing and response monitoring, as well as high levels of impulsiveness, regardless of the pattern of crack and/or cocaine consumption (recreational or chronic). Former users showed high levels of impulsiveness even after long periods of abstinence. Conclusions Crack and/or cocaine users may have inhibitory control deficits, irrespective of different consumption patterns. High levels of impulsiveness can represent a factor of vulnerability to drug use and relapse.

Keywords

Drugs, assessment, inhibition, cognition

Resumo

Resumo Objetivo Prejuízos envolvendo o controle inibitório têm sido considerados déficits centrais em usuários de substâncias psicoativas, contudo parece haver disfunções específicas de acordo com a droga de escolha. Este artigo teve por objetivo revisar os achados recentes sobre alterações do controle inibitório em amostras de usuários de cocaína e/ou crack. Método A pesquisa foi realizada nas bases de dados PubMed, PsycINFO e Web of Knowledge, em duas etapas, de acordo com os critérios de elegibilidade: inicialmente foi feita uma pesquisa nas bases de dados com análise dos títulos e resumos; após, os artigos foram lidos na íntegra. Os critérios de inclusão foram: artigos empíricos publicados em inglês, português ou espanhol, nos últimos 10 anos e que tenham avaliado o controle inibitório em usuários de cocaína e/ou crack. Resultados Do total de 3.796 resultados, 56 títulos foram selecionados, sendo 20 excluídos. Como resultado, 36 artigos foram incluídos na revisão. Em 90% dos estudos revisados, foi relatada a presença de déficits de controle inibitório, verificados através de prejuízos no processamento cognitivo e no monitoramento de respostas, além de níveis elevados de impulsividade, independentemente do padrão de consumo de cocaína e/ou crack (uso recreativo ou crônico). Usuários em abstinência apresentaram níveis elevados de impulsividade, mesmo após longos períodos sem uso da droga. Conclusão Usuários de cocaína e/ou crack podem apresentar prejuízos de controle inibitório apesar dos diferentes padrões de consumo. Níveis elevados de impulsividade podem constituir fator de vulnerabilidade para o uso de drogas e para a recaída.

Palavras-chave

Drogas, avaliação, inibição, cognição

References

Faller S, Peuker AC, Sordi A, Stolf A, Souza-Formigoni ML, Cruz MS. Who seeks public treatment for substance abuse in Brazil? Results of a multicenter study involving four Brazilian state capitals. Trends Psychiatry Psychother. 2014;36:193-202.

Haas C, Karila L, Lowenstein W. Cocaine and crack addiction: a growing public health problem. Bull Acad Natl Med. 2009;193:947-62.

Diehl A, Cordeiro DC, Laranjeira R. Dependência química: prevenção, tratamento e políticas públicas. 2011.

Friedman AS, Glassman K, Terras BA. Violent behavior as related to use of marijuana and other drugs. J Addict Dis. 2001;20:49-72.

Ribeiro M, Dunn J, Sesso R, Dias AC, Laranjeira R. Causes of death among crack cocaine users. Rev Bras Psiquiatr. 2006;28:196-202.

Riezzo I, Fiore C, De Carlo D, Pascale N, Neri M, Turillazzi E. Side effects of cocaine abuse: multiorgan toxicity and pathological consequences. Curr Med Chem. 2012;19:5624-46.

Carlini EA, Galduróz JCF, Noto AR, Fonseca AM, Carlini CM, Oliveira LG. II Levantamento domiciliar sobre uso de drogas psicotrópicas no Brasil: estudo envolvendo as 108 maiores cidades do país – 2005. 2007.

Galduróz JC, Noto AR, Carlini EA. IV Levantamento sobre o uso de drogas entre estudantes de 1º e 2º graus em 10 capitais brasileiras. 1997.

da Cunha SM, Araujo RB, Bizarro L. Profile and pattern of crack consumption among impatients in a Brazilian psychiatric hospital. Trends Psychiatry Psychother. 2015;37:126-32.

Pedrero-Perez EJ, Rojo-Mota G, Ruiz-Sanchez de Leon JM, Llanero-Luque M, Puerta-Garcia C. Cognitive remediation in addictions treatment. Rev Neurol. 2011;52:163-72.

Suska A, Lee BR, Huang YH, Dong Y, Schluter OM. Selective presynaptic enhancement of the prefrontal cortex to nucleus accumbens pathway by cocaine. Proc Natl Acad Sci U S A. 2013;110:713-8.

Volkow ND, Fowler JS. Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb Cortex. 2000;10:318-25.

Volkow ND, Fowler JS, Wang GJ. The addicted human brain: insights from imaging studies. J Clin Invest. 2003;111:1444-51.

Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol. 1995;51:768-74.

Pedrero-Perez EJ, Ruiz Sánchez de León JM. Subtypes of cocaine addicts with and without associated problematic alcohol use: towards a neuropsychology of personality applied to clinical practice. Adicciones. 2012;24:291-300.

Moeller FG, Barratt ES, Dougherty DM, Schmitz JM, Swann AC. Psychiatric aspects of impulsivity. Am J Psychiatry. 2001;158:1783-93.

Colzato LS, Hommel B. Recreational use of cocaine eliminates inhibition of return. Neuropsychology. 2009;23:125-9.

Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology. 2010;35:217-38.

RMMd Almeida, Hammer C, Macuglia GR, Klein LA, Trentini LB, Tesmmer M. Uso de álcool, drogas, níveis de impulsividade e agressividade em adolescentes do Rio Grande do Sul. Psico (Porto Alegre). 2014;45:65-72.

Verdejo-Garcia A, Perez-Garcia M. Profile of executive deficits in cocaine and heroin polysubstance users: common and differential effects on separate executive components. Psychopharmacology (Berl). 2007;190:517-30.

Camí J, Farré M. Drug addiction. N Engl J Med. 2003;349:975-86.

Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). 2013.

Fillmore MT, Rush CR, Hays L. Cocaine improves inhibitory control in a human model of response conflict. Exp Clin Psychopharmacol. 2005;13:327-35.

Fillmore MT, Rush CR, Hays L. Acute effects of cocaine in two models of inhibitory control: implications of non-linear dose effects. Addiction. 2006;101:1323-32.

Albein-Urios N, Martinez-Gonzalez JM, Lozano O, Clark L, Verdejo-Garcia A. Comparison of impulsivity and working memory in cocaine addiction and pathological gambling: implications for cocaine-induced neurotoxicity. Drug Alcohol Depend. 2012;126:1-6.

Albein-Urios N, Martinez-Gonzalez JM, Lozano-Rojas O, Verdejo-Garcia A. Executive functions in cocaine-dependent patients with Cluster B and Cluster C personality disorders. Neuropsychology. 2014;28:84-90.

Colzato LS, van den Wildenberg WP, Hommel B. Impaired inhibitory control in recreational cocaine users. Plos One. 2007;2.

Fillmore MT, Rush CR. Polydrug abusers display impaired discrimination-reversal learning in a model of behavioural control. J Psychopharmacol. 2006;20:24-32.

Fernández-Serrano MJ, Pérez-García M, Schmidt Río-Valle J, Verdejo-García A. Neuropsychological consequences of alcohol and drug abuse on different components of executive functions. J Psychopharmacol. 2010;24:1317-32.

Fernández-Serrano MJ, Perales JC, Moreno-López L, Pérez-García M, Verdejo-García A. Neuropsychological profiling of impulsivity and compulsivity in cocaine dependent individuals. Psychopharmacology (Berl). 2012;219:673-83.

Hester R, Simões-Franklin C, Garavan H. Post-error behavior in active cocaine users: poor awareness of errors in the presence of intact performance adjustments. Neuropsychopharmacology. 2007;32:1974-84.

Sellaro R, Hommel B, Colzato LS. Increased response conflict in recreational cocaine polydrug users. Exp Brain Res. 2014;232:113-9.

Kjome KL, Lane SD, Schmitz JM, Green C, Ma L, Prasla I. Relationship between impulsivity and decision making in cocaine dependence. Psychiatry Res. 2010;178:299-304.

Li CS, Milivojevic V, Kemp K, Hong K, Sinha R. Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence. Drug Alcohol Depend. 2006;85:205-12.

Liu S, Lane SD, Schmitz JM, Green CE, Cunningham KA, Moeller FG. Increased intra-individual reaction time variability in cocaine-dependent subjects: role of cocaine-related cues. Addict Behav. 2012;37:193-7.

Madoz-Gurpide A, Blasco-Fontecilla H, Baca-Garcia E, Ochoa-Mangado E. Executive dysfunction in chronic cocaine users: an exploratory study. Drug Alcohol Depend. 2011;117:55-8.

Pike E, Marks KR, Stoops WW, Rush CR. Cocaine-related stimuli impair inhibitory control in cocaine users following short stimulus onset asynchronies. Addiction. 2015;110:1281-6.

Ruiz MJ, Paolieri D, Colzato LS, Bajo MT. Chronic and recreational use of cocaine is associated with a vulnerability to semantic interference. Psychopharmacology (Berl). 2015;232:1717-26.

Soar K, Dawkins L, Page F, Wooldridge J. Recreational cocaine use is associated with attenuated latent inhibition. Addict Behav. 2015;50:34-9.

van der Plas EA, Crone EA, van den Wildenberg WP, Tranel D, Bechara A. Executive control deficits in substance-dependent individuals: a comparison of alcohol, cocaine, and methamphetamine and of men and women. J Clin Exp Neuropsychol. 2009;31:706-19.

Verdejo-Garcia AJ, Lopez-Torrecillas F, Aguilar de Arcos F, Perez-Garcia M. Differential effects of MDMA, cocaine, and cannabis use severity on distinctive components of the executive functions in polysubstance users: a multiple regression analysis. Addict Behav. 2005;30:89-101.

Verdejo-Garcia AJ, Perales JC, Perez-Garcia M. Cognitive impulsivity in cocaine and heroin polysubstance abusers. Addict Behav. 2007;32:950-66.

Vonmoos M, Hulka LM, Preller KH, Jenni D, Schulz C, Baumgartner MR. Differences in self-reported and behavioral measures of impulsivity in recreational and dependent cocaine users. Drug Alcohol Depend. 2013;133:61-70.

Winhusen T, Lewis D, Adinoff B, Brigham G, Kropp F, Donovan DM. Impulsivity is associated with treatment non-completion in cocaine- and methamphetamine-dependent patients but differs in nature as a function of stimulant-dependence diagnosis. J Subst Abuse Treat. 2013;44:541-7.

Albein-Urios N, Martinez-Gonzalez JM, Lozano O, Moreno-Lopez L, Soriano-Mas C, Verdejo-Garcia A. Negative urgency, disinhibition and reduced temporal pole gray matter characterize the comorbidity of cocaine dependence and personality disorders. Drug Alcohol Depend. 2013;132:231-7.

Barros-Loscertales A, Bustamante JC, Ventura-Campos N, Llopis JJ, Parcet MA, Avila C. Lower activation in the right frontoparietal network during a counting Stroop task in a cocaine-dependent group. Psychiatry Res. 2011;194:111-8.

Bell RP, Foxe JJ, Ross LA, Garavan H. Intact inhibitory control processes in abstinent drug abusers (I): a functional neuroimaging study in former cocaine addicts. Neuropharmacology. 2014;82:143-50.

Bell RP, Garavan H, Foxe JJ. Neural correlates of craving and impulsivity in abstinent former cocaine users: towards biomarkers of relapse risk. Neuropharmacology. 2014;85:461-70.

Castelluccio BC, Meda SA, Muska CE, Stevens MC, Pearlson GD. Error processing in current and former cocaine users. Brain Imaging Behav. 2014;8:87-96.

Connolly CG, Foxe JJ, Nierenberg J, Shpaner M, Garavan H. The neurobiology of cognitive control in successful cocaine abstinence. Drug Alcohol Depend. 2012;121:45-53.

Elton A, Young J, Smitherman S, Gross RE, Mletzko T, Kilts CD. Neural network activation during a stop-signal task discriminates cocaine-dependent from non-drug-abusing men. Addict Biol. 2014;19:427-38.

Hester R, Bell RP, Foxe JJ, Garavan H. The influence of monetary punishment on cognitive control in abstinent cocaine-users. Drug Alcohol Depend. 2013;133:86-93.

Morie KP, De Sanctis P, Garavan H, Foxe JJ. Executive dysfunction and reward dysregulation: a high-density electrical mapping study in cocaine abusers. Neuropharmacology. 2014;85:397-407.

Morie KP, Garavan H, Bell RP, De Sanctis P, Krakowski MI, Foxe JJ. Intact inhibitory control processes in abstinent drug abusers (II): a high-density electrical mapping study in former cocaine and heroin addicts. Neuropharmacology. 2014;82:151-60.

Morein-Zamir S, Simon Jones P, Bullmore ET, Robbins TW, Ersche KD. Prefrontal hypoactivity associated with impaired inhibition in stimulant-dependent individuals but evidence for hyperactivation in their unaffected siblings. Neuropsychopharmacology. 2013;38:1945-53.

Smith DG, Jones PS, Bullmore ET, Robbins TW, Ersche KD. Cognitive control dysfunction and abnormal frontal cortex activation in stimulant drug users and their biological siblings. Transl Psychiatry. 2013;3.

Bradley BP, Mogg K, Wright T, Field M. Attentional bias in drug dependence: vigilance for cigarette-related cues in smokers. Psychol Addict Behav. 2003;17:66-72.

Peuker AC, Lopes FM, Bizarro L. Viés atencional no abuso de drogas: teoria e método. Psic Teor Pesq. 2009;25:603-9.

Williams JM, Mathews A, MacLeod C. The emotional Stroop task and psychopathology. Psychol Bull. 1996;120:3-24.

Liu S, Lane SD, Schmitz JM, Waters AJ, Cunningham KA, Moeller FG. Relationship between attentional bias to cocaine-related stimuli and impulsivity in cocaine-dependent subjects. Am J Drug Alcohol Abuse. 2011;37:117-22.

Luo X, Zhang S, Hu S, Bednarski SR, Erdman E, Farr OM. Error processing and gender-shared and specific neural predictors of relapse in cocaine dependence. Brain. 2013;136:1231-44.

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